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Article

Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism.

The Journal of clinical investigation - 1 Mar 2000

Yu S, Gavrilova O, Chen H, Lee R, Liu J, Pacak K, Parlow A F, Quon M J, Reitman M L, Weinstein L S

Abstract excerpt

Heterozygous disruption of Gnas, the gene encoding the stimulatory G-protein alpha subunit (G(s)alpha), leads to distinct phenotypes depending on whether the maternal (m-/+) or paternal (+/p-) allele is disrupted. G(s)alpha is imprinted, with the maternal allele preferentially expressed in adipos...

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Source

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Identifiers

PMID: 10712433
DOI: 10.1172/JCI8437
PMCID: PMC289181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10712433-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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