Article
Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention.
Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 2000
Swanson J, Oosterlaan J, Murias M, Schuck S, Flodman P, Spence M A, Wasdell M, Ding Y, Chi H C, Smith M, Mann M, Carlson C, Kennedy J L, Sergeant J A, Leung P, Zhang Y P, Sadeh A, Chen C, Whalen C K, Babb K A, Moyzis R, Posner M I
Abstract excerpt
An association of the dopamine receptor D4 (DRD4) gene located on chromosome 11p15.5 and attention deficit/hyperactivity disorder (ADHD) has been demonstrated and replicated by multiple investigators. A specific allele [the 7-repeat of a 48-bp variable number of tandem repeats (VNTR) in exon 3] has been proposed as an etiological factor in attentional deficits manifested in some children diagnosed with this...
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