Article
Novel mutations in the SH3BP2 gene associated with sporadic central giant cell lesions and cherubism.
Oral diseases - 1 Jan 2009
Carvalho V M, Perdigão P F, Amaral F R, de Souza P E A, De Marco L, Gomez R S
Abstract excerpt
Central giant cell lesion (CGCL) is a reactive bone lesion that occurs mainly in the mandible, characterized by the multinucleated osteoclast-like giant cells in a background of oval to spindle-shaped mononuclear cells. The etiology is unknown and occurs more commonly in young adults. Cherubism, a rare disease found predominantly in females has histologic characteristics indistinguishable from those of CGCL and...
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