Article
Steroidogenic regulatory factor FOS is underexpressed in polycystic ovary syndrome (PCOS) adipose tissue and genetically associated with PCOS susceptibility.
The Journal of clinical endocrinology and metabolism - 1 Sept 2012
Jones Michelle R, Chazenbalk Gregorio, Xu Ning, Chua Angela K, Eigler Tamar, Mengesha Emebet, Chen Yen-Hao, Lee Jung-Min, Pall Marita, Li Xiaohui, Chen Yii-Der I, Taylor Kent D, Mathur Ruchi, Krauss Ronald M, Rotter Jerome I, Legro Richard S, Azziz Ricardo, Goodarzi Mark O
Abstract excerpt
CONTEXT: Polycystic ovary syndrome (PCOS) is a heterogeneous common genetic disorder characterized by hyperandrogenemia and insulin resistance. Alterations in gene expression profiles of the ovary and adipose tissue identified the candidate gene FBJ murine osteosarcoma viral oncogene homolog (FOS) for further investigation of expression changes in metabolic tissues and genetic studies. OBJECTIVE: The objective of...
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