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Article

Genetic and gene expression analyses of the polycystic ovary syndrome candidate gene fibrillin-3 and other fibrillin family members in human ovaries.

Molecular human reproduction - 1 Dec 2009

Prodoehl Mark J, Hatzirodos Nicholas, Irving-Rodgers Helen F, Zhao Zhen Z, Painter Jodie N, Hickey Theresa E, Gibson Mark A, Rainey William E, Carr Bruce R, Mason Helen D, Norman Robert J, Montgomery Grant W, Rodgers Raymond J

Abstract excerpt

Several studies have demonstrated an association between polycystic ovary syndrome (PCOS) and the dinucleotide repeat microsatellite marker D19S884, which is located in intron 55 of the fibrillin-3 (FBN3) gene. Fibrillins, including FBN1 and 2, interact with latent transforming growth factor (TGF)-beta-binding proteins (LTBP) and thereby control the bioactivity of TGFbetas. TGFbetas stimulate fibroblast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19692420
DOI: 10.1093/molehr/gap072
PMCID: PMC2776474

Genes

FBN3
FBN1
FBN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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