Article
Effects of mutations in the X gene of hepatitis B virus on the virus replication.
Acta virologica - 1 Jan 2012
Yu Hui, Zhu Rong, Zhu Ya-Zhen, Chen Qi, Zhu Hong-Guang
Abstract excerpt
UNLABELLED: Previously, we have found a new mutation at nt 1726-1730 that is associated with lower hepatitis B virus (HBV) DNA levels in the liver, and mutations at nt 1762/1764 that are correlated with higher HBV DNA levels. To confirm the effects of these mutations on the virus replication efficiency, substitutions nt 1726-1730 CTGAG and A1762T/G1764A in the HBV X (HBX) gene region were investigated alone or in...
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