Article
The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients.
Anticancer research - 1 Aug 2009
Tahara Tomomitsu, Shibata Tomoyuki, Arisawa Tomiyasu, Nakamura Masakatsu, Yoshioka Daisuke, Okubo Masaaki, Maruyama Naoko, Kamano Toshiaki, Kamiya Yoshio, Fujita Hiroshi, Nagasaka Mitsuo, Iwata Masami, Yamashita Hiromi, Nakano Hiroshi, Hirata Ichiro
Abstract excerpt
BACKGROUND: Heat-shock protein (HSP) 70 plays essential roles in cellular response to a variety of environmental stresses or unfavorable conditions. A to G transition at the 1267 position of the HSP70-2 gene confers different levels of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of premalignant condition, on the degree of acute or chronic inflammation in the stomach....
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