Article
Genetic polymorphisms of CYP17A1 in steroidogenesis pathway are associated with risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy.
International journal of clinical oncology - 1 Aug 2013
Yamada Takeshi, Nakayama Masashi, Shimizu Tomohito, Nonen Shinpei, Nakai Yasutomo, Nishimura Kazuo, Fujio Yasushi, Okuyama Akihiko, Azuma Junichi, Nonomura Norio
Abstract excerpt
BACKGROUND: Hormone ablation therapy is the standard therapy for prostate cancer; however, there are large individual differences in the duration of response to the therapy. We investigated, in this retrospective multicenter study, the association between genetic polymorphic variations in steroidogenesis-related genes and the risk of progression to castration-resistant prostate cancer (CRPC) in Japanese patients...
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