Article
CYP17A1 polymorphisms and clinical outcome of castration-resistant prostate cancer patients treated with abiraterone.
The International journal of biological markers - 30 Jul 2016
Salvi Samanta, Casadio Valentina, Burgio Salvatore Luca, Conteduca Vincenza, Rossi Lorena, Menna Cecilia, Carretta Elisa, Costantini Matteo, Zoli Wainer, De Giorgi Ugo
Abstract excerpt
BACKGROUND: We evaluated the role of single nucleotide polymorphisms in the CYP17A1 gene for predicting clinical outcome in castration-resistant prostate cancer (CRPC) patients treated with abiraterone. METHODS: Sixty-four patients were genotyped for the selected polymorphisms (rs743572, rs10883783, rs17115100 and rs284849) in CYP17A1. We hypothesized that different genotypes could be associated with...
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