Genetic variations in genes involved in testosterone metabolism are associated with prostate cancer progression: A Spanish multicenter study.

doi:10.1016/j.urolonc.2015.04.003

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Article

Genetic variations in genes involved in testosterone metabolism are associated with prostate cancer progression: A Spanish multicenter study.

Urologic oncology - 1 Jul 2015

Henríquez-Hernández Luis Alberto, Valenciano Almudena, Foro-Arnalot Palmira, Álvarez-Cubero María Jesús, Cozar José Manuel, Suárez-Novo José Francisco, Castells-Esteve Manel, Fernández-Gonzalo Pablo, De-Paula-Carranza Belén, Ferrer Montse, Guedea Ferrán, Sancho-Pardo Gemma, Craven-Bartle Jordi, Ortiz-Gordillo María José, Cabrera-Roldán Patricia, Rodríguez-Melcón Juan Ignacio, Herrera-Ramos Estefanía, Rodríguez-Gallego Carlos, Lara Pedro C

Abstract excerpt

BACKGROUND: Prostate cancer (PCa) is an androgen-dependent disease. Nonetheless, the role of single nucleotide polymorphisms (SNPs) in genes encoding androgen metabolism remains an unexplored area. PURPOSE: To investigate the role of germline variations in cytochrome P450 17A1 (CYP17A1) and steroid-5α-reductase, α-polypeptides 1 and 2 (SRD5A1 and SRD5A2) genes in PCa. PATIENTS AND METHODS: In total, 494...

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PMID: 25960412
DOI: 10.1016/j.urolonc.2015.04.003

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