Article
Rediscovering the value of families for psychiatric genetics research.
Molecular psychiatry - 1 Apr 2019
Glahn David C, Nimgaonkar Vishwajit L, Raventós Henriette, Contreras Javier, McIntosh Andrew M, Thomson Pippa A, Jablensky Assen, McCarthy Nina S, Charlesworth Jac C, Blackburn Nicholas B, Peralta Juan Manuel, Knowles Emma E M, Mathias Samuel R, Ament Seth A, McMahon Francis J, Gur Ruben C, Bucan Maja, Curran Joanne E, Almasy Laura, Gur Raquel E, Blangero John
Abstract excerpt
As it is likely that both common and rare genetic variation are important for complex disease risk, studies that examine the full range of the allelic frequency distribution should be utilized to dissect the genetic influences on mental illness. The rate limiting factor for inferring an association between a variant and a phenotype is inevitably the total number of copies of the minor allele captured in the...
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