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Article

Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin.

Biochimica et biophysica acta - 1 Oct 2012

Gerard Brigitte, Sanders Matthew A, Visscher Daniel W, Tait Larry, Shekhar Malathy P V

Abstract excerpt

The ubiquitin conjugating enzyme Rad6B is overexpressed in breast cancer and induces β-catenin transcriptional activation and stabilization via K63-linked polyubiquitination. Here we identify β-catenin and Rad6B interacting regions, identify potential Rad6B ubiquitination sites in β-catenin, and characterize their breast cancer tissue expression. β-catenin and Rad6B colocalize in breast carcinoma and...

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Identifiers

PMID: 22705350
DOI: 10.1016/j.bbamcr.2012.05.032
PMCID: PMC3915360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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