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Article

Myeloproliferative neoplasms: molecular pathophysiology, essential clinical understanding, and treatment strategies.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Feb 2011

Tefferi Ayalew, Vainchenker William

Abstract excerpt

To update oncologists on pathogenesis, contemporary diagnosis, risk stratification, and treatment strategies in BCR-ABL1-negative myeloproliferative neoplasms, including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Recent literature was reviewed and interpreted in the context of the authors' own experience and expertise. Pathogenetic mechanisms in PV, ET, and PMF...

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Topics

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21220604
DOI: 10.1200/JCO.2010.29.8711

Genes

JAK2
ABL1
ASXL1
BCR
CBL
IKZF1
MPL
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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