Article
Membrane Type 1 Matrix Metalloproteinase induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells.
BMC cancer - 1 Apr 2013
Yang Cong-Chong, Zhu Li-Fang, Xu Xiao-Hui, Ning Tian-Yun, Ye Jin-Hai, Liu Lai-Kui
Abstract excerpt
BACKGROUND: Tissue invasion and metastasis are acquired abilities of cancer and related to the death in oral squamous cell carcinoma (OSCC). Emerging observations indicate that the epithelial-to-mesenchymal transition (EMT) is associated with tumor progression and the generation of cells with cancer stem cells (CSCs) properties. Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) is a cell surface proteinase,...
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