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Mechanisms in decorin regulation of vascular endothelial growth factor-induced human trophoblast migration and acquisition of endothelial phenotype.

Biology of reproduction - 1 Sept 2012

Lala Neena, Girish Gannareddy V, Cloutier-Bosworth Alia, Lala Peeyush K

Abstract excerpt

Extravillous trophoblast (EVT) cells of the human placenta invade the uterine decidua and utero-placental arteries to establish an efficient exchange of key molecules between maternal and fetal blood. Trophoblast invasion is stringently regulated in situ both positively and negatively by a variety of factors at the fetal-maternal interface to maintain a healthy utero-placental homeostasis. One such factor,...

Topics

Cell Differentiation
Cell Movement
Cells, Cultured
Decorin
Drug Antagonism
Endothelium, Vascular
Female
Human Umbilical Vein Endothelial Cells
Humans
Neovascularization, Physiologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Pregnancy

Signal Transduction

Trophoblasts

Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 22699486
DOI: 10.1095/biolreprod.111.097881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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