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Human trophoblast stem cell self-renewal and differentiation: Role of decorin

6 Jun 2018

Abstract excerpt

The origin and regulation of stem cells sustaining trophoblast renewal in the human placenta remain unclear. Decorin, a leucine-rich proteoglycan restrains trophoblast proliferation, migration/invasiveness and endovascular differentiation, and local decorin overproduction is associated with preeclampsia (PE). Here, we tested the role of decorin in human trophoblast stem cell self-renewal and differentiation,...

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PMID: 29895842
DOI: 10.1038/s41598-018-27119-4

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