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Article

Casein kinase 2α regulates multidrug resistance-associated protein 1 function via phosphorylation of Thr249.

Molecular pharmacology - 1 Sept 2012

Stolarczyk Elzbieta I, Reiling Cassandra J, Pickin Kerry A, Coppage Ryan, Knecht Marc R, Paumi Christian M

Abstract excerpt

We have shown previously that the function of Ycf1p, yeast ortholog of multidrug resistance-associated protein 1 (MRP1), is regulated by yeast casein kinase 2α (Cka1p) via phosphorylation at Ser251. In this study, we explored whether casein kinase 2α (CK2α), the human homolog of Cka1p, regulates MRP1 by phosphorylation at the semiconserved site Thr249. Knockdown of CK2α in MCF7-derived cells expressing MRP1 [MRP1...

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Identifiers

PMID: 22695718
DOI: 10.1124/mol.112.078295
PMCID: PMC3422697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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