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Article

Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region.

The Journal of biological chemistry - 17 Dec 2004

Westlake Christopher J, Payen Lea, Gao Mian, Cole Susan P C, Deeley Roger G

Abstract excerpt

The ATP binding cassette (ABC) transporter, multidrug resistance protein 1 (MRP1/ABCC1), transports a broad spectrum of conjugated and unconjugated compounds, including natural product chemotherapeutic agents. In this study, we have investigated the importance of the COOH-terminal region of MRP1 for transport activity and basolateral plasma membrane trafficking. The COOH-terminal regions of some ABCC proteins...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Adenosine Triphosphate
Amino Acid Sequence
Animals
Cell Line
Cell Membrane
Codon
Crystallography, X-Ray
Cytoplasm
Dogs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Dose-Response Relationship, Drug

Enhancer Elements, Genetic

Hydrolysis

Immunoblotting

Insecta

Kinetics

Leukotriene C4

Molecular Sequence Data

Source

Identifiers

PMID: 15459206
DOI: 10.1074/jbc.M402528200

Genes

ABCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region.PMID 15459206Read ↗

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