Article
Sequencing ASMT identifies rare mutations in Chinese Han patients with autism.
PloS one - 1 Jan 2013
Wang Lifang, Li Jun, Ruan Yanyan, Lu Tianlan, Liu Chenxing, Jia Meixiang, Yue Weihua, Liu Jing, Bourgeron Thomas, Zhang Dai
Abstract excerpt
Melatonin is involved in the regulation of circadian and seasonal rhythms and immune function. Prior research reported low melatonin levels in autism spectrum disorders (ASD). ASMT located in pseudo-autosomal region 1 encodes the last enzyme of the melatonin biosynthesis pathway. A previous study reported an association between ASD and single nucleotide polymorphisms (SNPs) rs4446909 and rs5989681 located in the...
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