Article
Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma.
Endocrine pathology - 1 Jan 2006
Nakamura Eijiro, Kaelin William G
Abstract excerpt
Pheochromocytomas and paragangliomas are rare tumors derived from chromaffin cells. These tumors can arise in the context of hereditary cancer syndromes such as von Hippel- Lindau disease, multiple endocrine neoplasia type 2, and neurofibromatosis 1. Recent studies indicate that germ line mutations of genes encoding specific succinate dehydrogenase (SDH) subunits also predispose individuals to pheochromocytomas...
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