Article
Association of the adrenergic alpha2A receptor gene with methylphenidate improvement of inattentive symptoms in children and adolescents with attention-deficit/hyperactivity disorder.
Archives of general psychiatry - 1 Feb 2007
Polanczyk Guilherme, Zeni Cristian, Genro Julia P, Guimarães Ana P, Roman Tatiana, Hutz Mara H, Rohde Luis A
Abstract excerpt
CONTEXT: Preclinical studies have demonstrated the relevance of adrenergic alpha2A receptor on the attentional process and the mechanism of action of methylphenidate hydrochloride. Several molecular genetic investigations suggest a role for the adrenergic alpha2A receptor gene (ADRA2A) in attention-deficit/hyperactivity disorder (ADHD), especially in the inattentive dimension. However, the effect of ADRA2A in the...
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