Article
Attenuating the emergence of anti-fungal drug resistance by harnessing synthetic lethal interactions in a model organism
19 Aug 2019
Abstract excerpt
Drug resistance is a rapidly emerging concern, thus prompting the development of novel therapeutics or combinatorial therapy.Currently, combinatorial therapy targets are based on knowledge of drug mode of action and/or resistance mechanisms, constraining the number of target proteins.Unbiased genome-wide screens could reveal novel genetic components within interaction networks as potential targets in combination...
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