Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.

doi:10.1371/journal.pgen.1002753

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Article

Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.

PLoS genetics - 1 Jan 2012

Fan Qiao, Barathi Veluchamy A, Cheng Ching-Yu, Zhou Xin, Meguro Akira, Nakata Isao, Khor Chiea-Chuen, Goh Liang-Kee, Li Yi-Ju, Lim Wan'e, Ho Candice E H, Hawthorne Felicia, Zheng Yingfeng, Chua Daniel, Inoko Hidetoshi, Yamashiro Kenji, Ohno-Matsui Kyoko, Matsuo Keitaro, Matsuda Fumihiko, Vithana Eranga, Seielstad Mark, Mizuki Nobuhisa, Beuerman Roger W, Tai E-Shyong, Yoshimura Nagahisa, Aung Tin, Young Terri L, Wong Tien-Yin, Teo Yik-Ying, Saw Seang-Mei

Abstract excerpt

As one of the leading causes of visual impairment and blindness, myopia poses a significant public health burden in Asia. The primary determinant of myopia is an elongated ocular axial length (AL). Here we report a meta-analysis of three genome-wide association studies on AL conducted in 1,860 Chinese adults, 929 Chinese children, and 2,155 Malay adults. We identified a genetic locus on chromosome 1q41 harboring...

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PMID: 22685421
DOI: 10.1371/journal.pgen.1002753
PMCID: PMC3369958

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LYPLAL1

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