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Global regulator engineering significantly improved Escherichia coli tolerances toward inhibitors of lignocellulosic hydrolysates.

Biotechnology and bioengineering - 1 Dec 2012

Wang Jianqing, Zhang Yan, Chen Yilu, Lin Min, Lin Zhanglin

Abstract excerpt

Lignocellulosic biomass is regarded as the most viable source of feedstock for industrial biorefinery, but the harmful inhibitors generated from the indispensable pretreatments prior to fermentation remain a daunting technical hurdle. Using an exogenous regulator, irrE, from the radiation-resistant Deinococcus radiodurans, we previously showed that a novel global regulator engineering (GRE) approach significantly...

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PMID: 22684885
DOI: 10.1002/bit.24574

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