Article
Laboratory-evolved mutants of an exogenous global regulator, IrrE from Deinococcus radiodurans, enhance stress tolerances of Escherichia coli.
PloS one - 18 Jan 2011
Chen Tingjian, Wang Jianqing, Yang Rong, Li Jicong, Lin Min, Lin Zhanglin
Abstract excerpt
BACKGROUND: The tolerance of cells toward different stresses is very important for industrial strains of microbes, but difficult to improve by the manipulation of single genes. Traditional methods for enhancing cellular tolerances are inefficient and time-consuming. Recently, approaches employing global transcriptional or translational engineering methods have been increasingly explored. We found that an...
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