Article
Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).
Developmental cell - 1 Dec 2002
Guertin David A, Venkatram Srinivas, Gould Kathleen L, McCollum Dannel
Abstract excerpt
In the fission yeast Schizosaccharomyces pombe, the septation initiation network (SIN) triggers cytokinesis after mitosis. We investigated the relationship between Dma1p, a spindle checkpoint protein and cytokinesis inhibitor, and the SIN. Deletion of dma1 inactivates the spindle checkpoint and allows precocious SIN activation, while overexpressing Dma1p reduces SIN signaling. Dma1p seems to function by...
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