Article
Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population.
Biochimica et biophysica acta - 1 Oct 2012
Pál Zsuzsanna, Antal Péter, Srivastava Sanjeev Kumar, Hullám Gábor, Semsei Agnes F, Gál János, Svébis Mihály, Soós Györgyi, Szalai Csaba, André Sabine, Gordeeva Elena, Nagy György, Kaltner Herbert, Bovin Nicolai V, Molnár Mária Judit, Falus András, Gabius Hans-Joachim, Buzás Edit Irén
Abstract excerpt
BACKGROUND: Galectins are potent immune regulators, with galectin-8 acting as a pro-apoptotic effector on synovial fluid cells and thymocytes and stimulator on T-cells. To set a proof-of-principle example for risk assessment in autoimmunity, and for a mutation affecting physiological galectin sen...
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