Article
A novel function of Siglec-9 A391C polymorphism on T cell receptor signaling.
International archives of allergy and immunology - 1 Jan 2011
Cheong Kyung Ah, Chang Yoon-Seok, Roh Joo Young, Kim Bum-Jun, Kim Myung-Nam, Park Youn Min, Park Hai Jin, Kim Nam-Doo, Lee Chang-Hoon, Lee Ai-Young
Abstract excerpt
BACKGROUND: Sialic-acid-binding immunoglobulin-like lectins (Siglecs) are the best-characterized immunoglobulin-type lectins. There is a growing amount of data linking Siglec and autoimmune diseases. The recently identified Siglec-9 inhibits T cell receptor (TCR)-mediated signaling which has been...
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