Article
Nucleotide sequences of genes encoding the type II chloramphenicol acetyltransferases of Escherichia coli and Haemophilus influenzae, which are sensitive to inhibition by thiol-reactive reagents.
The Biochemical journal - 1 Dec 1990
Murray I A, Martinez-Suarez J V, Close T J, Shaw W V
Abstract excerpt
Sensitivity of enzymes to inhibition by thiol-reactive reagents is often presented as evidence for the possible involvement of cysteine residues in substrate binding and catalysis or to highlight possible important differences in structure and mechanism between closely related enzymes. The primar...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Chloramphenicol O-Acetyltransferase
- Cloning, Molecular
- Escherichia coli
- Genes, Bacterial
- Genetic Variation
- Haemophilus influenzae
- Isoenzymes
- Kinetics
- Models, Molecular
- Molecular Sequence Data
- Protein Conformation