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Article

Elimination of a reactive thiol group from the active site of chloramphenicol acetyltransferase.

The Biochemical journal - 1 Dec 1990

Lewendon A, Shaw W V

Abstract excerpt

1. The type III variant of chloramphenicol acetyltransferase (CATIII) is resistant to inactivation by ionizable modifying reagents such as 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) and iodoacetate, whereas it is sensitive to inhibition by similar but uncharged reagents, including 4,4'-dithiodipyridine, methyl methanethiolsulphonate (MMTS) and iodoacetamide. The target for these thiol-modifying reagents has been...

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Source

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Identifiers

PMID: 2268277
DOI: 10.1042/bj2720499
PMCID: PMC1149728

Genes

CAT
DTNB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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