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Article

Efficient serotype-dependent release of functional vector into the culture medium during adeno-associated virus manufacturing.

Human gene therapy - 1 Oct 2010

Vandenberghe Luk H, Xiao Ru, Lock Martin, Lin Jianping, Korn Michael, Wilson James M

Abstract excerpt

Vectors based on adeno-associated virus (AAV) are the subject of increasing interest as research tools and agents for in vivo gene therapy. A current limitation on the technology is the versatile and scalable manufacturing of vector. On the basis of experience with AAV2-based vectors, which remain strongly cell associated, AAV vector particles are commonly harvested from cell lysates, and must be extensively...

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Identifiers

PMID: 20649475
DOI: 10.1089/hum.2010.107
PMCID: PMC2957237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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