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Article

RNA-interference knockdown of Drosophila pigment dispersing factor in neuronal subsets: the anatomical basis of a neuropeptide's circadian functions.

PloS one - 14 Dec 2009

Shafer Orie T, Taghert Paul H

Abstract excerpt

BACKGROUND: In animals, neuropeptide signaling is an important component of circadian timekeeping. The neuropeptide pigment dispersing factor (PDF) is required for several aspects of circadian activity rhythms in Drosophila. METHODOLOGY/PRINCIPAL FINDINGS: Here we investigate the anatomical basis for PDF's various circadian functions by targeted PDF RNA-interference in specific classes of Drosophila neuron. We...

Topics

Abdomen
Aging
Animals
Circadian Rhythm
Darkness
Drosophila Proteins
Drosophila melanogaster
Gene Knockdown Techniques
Locomotion
Mutation
Neurons
Neuropeptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Interference

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Identifiers

PMID: 20011537
DOI: 10.1371/journal.pone.0008298
PMCID: PMC2788783

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PDF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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