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Article

The M2 haplotype in the ANXA5 gene is an independent risk factor for idiopathic small-for-gestational age newborns.

Molecular human reproduction - 1 Oct 2012

Tiscia G, Colaizzo D, Favuzzi G, Vergura P, Martinelli P, Margaglione M, Grandone E

Abstract excerpt

Hereditary thrombophilias can impair vascular placental functions and predispose to the birth of small-for-gestational age (SGA) babies. The placental anticoagulant protein annexin A5 (ANXA5) may contribute to this process. A functional haplotype (M2) within the ANXA5 gene is associated with fetal loss and venous thrombosis. This study investigated the prevalence of the M2 haplotype in a group of women with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22679123
DOI: 10.1093/molehr/gas023

Genes

ANXA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The M2 haplotype in the ANXA5 gene is an independent risk factor for idiopathic small-for-gestational age newborns.PMID 22679123Read ↗

Haplotype M2 in the annexin A5 (ANXA5) gene and the occurrence of obstetric complicationsSemantic proximity Read ↗

Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications.Semantic proximity Read ↗

Contribution of fetal ANXA5 gene promoter polymorphisms to the onset of pre-eclampsia.Semantic proximity Read ↗

Assessment of M2/ANXA5 haplotype as a risk factor in couples with placenta-mediated pregnancy complications.Semantic proximity Read ↗

Genetic analysis of ANXA5 haplotype and its effect on recurrent pregnancy loss.Semantic proximity Read ↗

M2/ANXA5 haplotype as a predisposition factor in Malay women and couples experiencing recurrent spontaneous abortion: a pilot study.Semantic proximity Read ↗

Further insights into the role of the annexin A5 M2 haplotype as recurrent pregnancy loss factor, assessing timing of miscarriage and partner risk.Semantic proximity Read ↗

Investigation of the Annexin A5 M2 haplotype in 500 white European couples who have experienced recurrent spontaneous abortion.Semantic proximity Read ↗

Annexin A5 Promoter Haplotype M2 Is Not a Risk Factor for Recurrent Pregnancy Loss in Northern Europe.Semantic proximity Read ↗

Reduced allele specific annexin A5 mRNA levels in placentas carrying the M2/ANXA5 allele.Semantic proximity Read ↗

Genetic variations in the annexin A5 gene and the risk of pregnancy-related venous thrombosis.Semantic proximity Read ↗

Maternal and paternal carriage of the annexin A5 M2 haplotype: a possible risk factor for recurrent implantation failure (RIF).Semantic proximity Read ↗

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