Molecular profiling reveals low- and high-grade forms of primary melanoma.

doi:10.1158/1078-0432.CCR-12-0343

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Molecular profiling reveals low- and high-grade forms of primary melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2012

Harbst Katja, Staaf Johan, Lauss Martin, Karlsson Anna, Måsbäck Anna, Johansson Iva, Bendahl Pär-Ola, Vallon-Christersson Johan, Törngren Therese, Ekedahl Henrik, Geisler Jürgen, Höglund Mattias, Höglund Markus, Ringnér Markus, Ringnér Mattias, Lundgren Lotta, Jirström Karin, Olsson Håkan, Ingvar Christian, Borg Åke, Tsao Hensin, Jönsson Göran

Abstract excerpt

PURPOSE: For primary melanomas, tumor thickness, mitotic rate, and ulceration are well-laid cornerstones of prognostication. However, a molecular exposition of melanoma aggressiveness is critically missing. We recently uncovered a four-class structure in metastatic melanoma, which predicts outcome and informs biology. This raises the possibility that a molecular structure exists even in the early stages of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

Share to Kaplan-Meier Estimate

Share to Melanoma

Share to Neoplasm Grading

Share to Neoplasm Metastasis

Share to Neoplasm Staging

Source

Open in PubMed Open full text

Identifiers

PMID: 22675174
DOI: 10.1158/1078-0432.CCR-12-0343
PMCID: PMC3467105

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular profiling reveals low- and high-grade forms of primary melanoma.PMID 22675174Read ↗

Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilitiesSemantic proximity Read ↗

Molecular stratification of metastatic melanoma using gene expression profiling: Prediction of survival outcome and benefit from molecular targeted therapy.Semantic proximity Read ↗

Classification of node-positive melanomas into prognostic subgroups using keratin, immune, and melanogenesis expression patternsSemantic proximity Read ↗

Genomic Classification of Cutaneous Melanoma.Semantic proximity Read ↗

Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes.Semantic proximity Read ↗

Molecular Pathology of Skin Melanoma: Epidemiology, Differential Diagnostics, Prognosis and Therapy PredictionSemantic proximity Read ↗

Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome.Semantic proximity Read ↗

Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma.Semantic proximity Read ↗

Toward a molecular classification of melanoma.Semantic proximity Read ↗

Gene Expression Profiling in Uveal Melanoma Reveals Two Molecular Classes and Predicts Metastatic DeathSemantic proximity Read ↗

Molecular characterisation of cutaneous melanoma: creating a framework for targeted and immune therapies.Semantic proximity Read ↗

Defining Melanoma Immune Biomarkers—Desert, Excluded, and Inflamed Subtypes—Using a Gene Expression Classifier Reflecting Intratumoral Immune Response and Stromal PatternsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.