Article
Molecular stratification of metastatic melanoma using gene expression profiling: Prediction of survival outcome and benefit from molecular targeted therapy.
Oncotarget - 20 May 2015
Cirenajwis Helena, Ekedahl Henrik, Lauss Martin, Harbst Katja, Carneiro Ana, Enoksson Jens, Rosengren Frida, Werner-Hartman Linda, Törngren Therese, Kvist Anders, Fredlund Erik, Bendahl Pär-Ola, Jirström Karin, Lundgren Lotta, Howlin Jillian, Borg Åke, Gruvberger-Saal Sofia K, Saal Lao H, Nielsen Kari, Ringnér Markus, Tsao Hensin, Olsson Håkan, Ingvar Christian, Staaf Johan, Jönsson Göran
Abstract excerpt
Melanoma is currently divided on a genetic level according to mutational status. However, this classification does not optimally predict prognosis. In prior studies, we have defined gene expression phenotypes (high-immune, pigmentation, proliferative and normal-like), which are predictive of survival outcome as well as informative of biology. Herein, we employed a population-based metastatic melanoma cohort and...
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