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Article

Global hypomethylation in hepatocellular carcinoma and its relationship to aflatoxin B<sub>1</sub>exposure

1 Jan 2012

Abstract excerpt

AIM: To determine global DNA methylation in paired hepatocellular carcinoma (HCC) samples using several different assays and explore the correlations between hypomethylation and clinical parameters and biomarkers, including that of aflatoxin B(1) exposure. METHODS: Using the radio labeled methyl acceptance assay as a measure of global hypomethylation, as well as two repetitive elements, including satellite 2...

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PMID: 22666524
DOI: 10.4254/wjh.v4.i5.169

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