Article
Reciprocal uniparental disomy in yeast.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2012
Andersen Sabrina L, Petes Thomas D
Abstract excerpt
In the diploid cells of most organisms, including humans, each chromosome is usually distinguishable from its partner homolog by multiple single-nucleotide polymorphisms. One common type of genetic alteration observed in tumor cells is uniparental disomy (UPD), in which a pair of homologous chromosomes are derived from a single parent, resulting in loss of heterozygosity for all single-nucleotide polymorphisms...
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