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Article

Perfusion Flow Enhances Viability and Migratory Phenotype in 3D-Cultured Breast Cancer Cells.

Annals of biomedical engineering - 1 Sept 2021

Pasini Alice, Lovecchio Joseph, Cortesi Marilisa, Liverani Chiara, Spadazzi Chiara, Mercatali Laura, Ibrahim Toni, Giordano Emanuele

Abstract excerpt

Conventional 2D cell culture, a traditional tool in pre-clinical studies, can hardly be regarded as a representation of a natural cell microenvironment. In this respect, it might result in altered cellular behaviors. To overcome such a limitation, different approaches have been tested to conduct more representative in vitro studies. In particular, the use of 3D cell culture introduces variables, such as cell-cell...

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Identifiers

PMID: 33543395
DOI: 10.1007/s10439-021-02727-w
PMCID: PMC8455496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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