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Article

New links between lipid accumulation and cancer progression

1 Apr 2018

Abstract excerpt

Individuals with elevated lipid levels are at risk for developing cardiovascular disease as well as cancer. Sterol regulatory element–binding protein transcription factors (SREBPs) are inducers of lipid synthesis. Elevated SREBPs levels are linked to cell proliferation and metastasis. Using biochemical and mouse models of cancer, Zhao et al. have discovered that nuclear SREBP-1a–dependent transcription is...

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Share to Cancer, Lipids, and Metabolism
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PMID: 29703762
DOI: 10.1074/jbc.h118.002654

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