Article
Phylogenetic Network Analyses Reveal the Influence of Transmission Clustering on the Spread of HIV Drug Resistance in Quebec from 2002 to 2022.
Viruses - 31 Jul 2024
Brenner Bluma G, Ibanescu Ruxandra-Ilinca, Oliveira Maureen, Margaillan Guillaume, Lebouché Bertrand, Thomas Réjean, Baril Jean Guy, Lorgeoux René-Pierre, Roger Michel, Routy Jean-Pierre, The Montreal Primary Hiv Infection Phi Cohort Study Group
Abstract excerpt
BACKGROUND: HIV drug resistance (HIV-DR) may jeopardize the benefit of antiretroviral therapy (ART) in treatment and prevention. This study utilized viral phylogenetics to resolve the influence of transmission networks on sustaining the spread of HIV-DR in Quebec spanning 2002 to 2022. METHODS: Time trends in acquired (ADR) and transmitted drug resistance (TDR) were delineated in treatment-experienced (n = 3500)...
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