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Article

pKa modulation of the acid/base catalyst within GH32 and GH68: a role in substrate/inhibitor specificity?

PloS one - 1 Jan 2012

Yuan Shuguang, Le Roy Katrien, Venken Tom, Lammens Willem, Van den Ende Wim, De Maeyer Marc

Abstract excerpt

Glycoside hydrolases of families 32 (GH32) and 68 (GH68) belong to clan GH-J, containing hydrolytic enzymes (sucrose/fructans as donor substrates) and fructosyltransferases (sucrose/fructans as donor and acceptor substrates). In GH32 members, some of the sugar substrates can also function as inhibitors, this regulatory aspect further adding to the complexity in enzyme functionalities within this family. Although...

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Identifiers

PMID: 22662155
DOI: 10.1371/journal.pone.0037453
PMCID: PMC3360783

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Source receipt: pubmed, retrieved 7 Sept 2026.

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