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Article

Significant association of SREBP-2 genetic polymorphisms with avascular necrosis in the Korean population.

BMC medical genetics - 27 Oct 2008

Kim Tae-Ho, Baek Jeong-In, Hong Jung Min, Choi Su-Jin, Lee Hye-Jin, Cho Hyun-Ju, Park Eui Kyun, Kim Un-Kyung, Kim Shin-Yoon

Abstract excerpt

BACKGROUND: It is known that steroid usage and alcohol abuse are major etiological factors in the development of avascular necrosis (AVN), a bone disease that produces osteonecrosis of the femoral head. The facilitation of fat biosynthesis by steroids and alcohol disrupts the blood supply into the femoral head. SREBP-2 plays a central role in the maintenance of lipid homeostasis through stimulating expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18954446
DOI: 10.1186/1471-2350-9-94
PMCID: PMC2600781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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