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Article

Progress of non-small-cell lung cancer with ROS1 rearrangement

22 Dec 2023

Abstract excerpt

ROS1 rearrangement is found in 0.9%–2.6% of people with non-small-cell lung cancers (NSCLCs). Tyrosine kinase inhibitors (TKIs) target ROS1 and can block tumor growth and provide clinical benefits to patients. This review summarizes the current knowledge on ROS1 rearrangements in NSCLCs, including the mechanisms of ROS1 oncogenicity, epidemiology of ROS1-positive tumors, methods for detecting rearrangements,...

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Identifiers

PMID: 38187090
DOI: 10.3389/fmolb.2023.1238093

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