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Article

High prevalence of ROS1 gene rearrangement detected by FISH in EGFR and ALK negative lung adenocarcinoma.

Experimental and molecular pathology - 1 Dec 2020

Xu Yuyin, Chang Heng, Wu Lijing, Zhang Xin, Zhang Ling, Zhang Jing, Li Yuan, Shen Lei, Zhu Xiaoli, Zhou Xiaoyan, Bai Qianming

Abstract excerpt

ROS1 rearrangement has become an important biomarker for targeted therapy in advanced lung adenocarcinoma (LUAD). The study aimed to evaluate the prevalence of ROS1 rearrangement in Chinese LUAD with EGFR wild-type and ALK fusion-negative status, and analyze the relationship with their clinicopathological characteristics. A large cohort of 589 patients of LUAD with EGFR/ALK wild-type, diagnosed between April 2014...

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PMID: 32979347
DOI: 10.1016/j.yexmp.2020.104548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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