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Article

Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2.

Nature medicine - 1 Jul 2012

Miyazaki Yu, Adachi Hiroaki, Katsuno Masahisa, Minamiyama Makoto, Jiang Yue-Mei, Huang Zhe, Doi Hideki, Matsumoto Shinjiro, Kondo Naohide, Iida Madoka, Tohnai Genki, Tanaka Fumiaki, Muramatsu Shin-ichi, Sobue Gen

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is an inherited neurodegenerative disorder caused by the expansion of the polyglutamine (polyQ) tract of the androgen receptor (AR-polyQ). Characteristics of SBMA include proximal muscular atrophy, weakness, contraction fasciculation and bulbar involvement. MicroRNAs (miRNAs) are a diverse class of highly conserved small RNA molecules that function as crucial regulators...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22660636
DOI: 10.1038/nm.2791

Genes

CELF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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