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Article

Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy.

Annals of neurology - 1 Feb 2009

Banno Haruhiko, Katsuno Masahisa, Suzuki Keisuke, Takeuchi Yu, Kawashima Motoshi, Suga Noriaki, Takamori Motoko, Ito Mizuki, Nakamura Tomohiko, Matsuo Koji, Yamada Shinichi, Oki Yumiko, Adachi Hiroaki, Minamiyama Makoto, Waza Masahiro, Atsuta Naoki, Watanabe Hirohisa, Fujimoto Yasushi, Nakashima Tsutomu, Tanaka Fumiaki, Doyu Manabu, Sobue Gen

Abstract excerpt

OBJECTIVE: Spinal and bulbar muscular atrophy (SBMA) is a hereditary motor neuron disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). Animal studies have shown that the pathogenesis of SBMA is dependent on serum testosterone level. This study is aimed at evalua...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19259967
DOI: 10.1002/ana.21540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19259967-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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