Article
[MicroRNA in neurodegenerative disorders].
Rinsho shinkeigaku = Clinical neurology - 1 Jan 2013
Sobue Gen
Abstract excerpt
MicroRNAs (miRNAs) bind to the 3'-untranslated region of mRNA, and thereby suppress the gene expression. Recent studies suggest that miRNAs modify the pathogenesis of cancer and neurodegeneration. Our study demonstrated that the expression levels of miR-196a is increased in a mouse model of spinal and bulbar muscular atrophy (SBMA), a neurodegenerative disease caused by the expansion of polyglutamine in androgen...
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