Improvement in clinical outcome of FLT3 ITD mutated acute myeloid leukemia patients over the last one and a half decade.

doi:10.1002/ajh.24140

Article

Improvement in clinical outcome of FLT3 ITD mutated acute myeloid leukemia patients over the last one and a half decade.

American journal of hematology - 1 Nov 2015

Badar Talha, Kantarjian Hagop M, Nogueras-Gonzalez Graciela M, Borthakur Gautam, Garcia Manero Guillermo, Andreeff Michael, Konopleva Marina, Kadia Tapan M, Daver Naval, Wierda William G, Luthra Raja, Patel Keyur, Oran Betul, Champlin Richard, Ravandi Farhad, Cortes Jorge E

Abstract excerpt

AML with FLT3 ITD mutations are associated with poor outcome. We reviewed outcomes of patients with FLT3 ITD mutated AML to investigate trends over time. We analyzed 224 AML patients (excluding patients with core binding factor and acute promyelocytic leukemia) referred to our institution between...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Antineoplastic Agents
Female
Gene Expression
Hematopoietic Stem Cell Transplantation
Humans

Leukemia, Myeloid, Acute

Male

Middle Aged

Mutation

Niacinamide

Phenylurea Compounds

Protein Kinase Inhibitors

Recurrence

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