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Article

A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer.

Molecular cancer research : MCR - 1 Dec 2017

Yochum Zachary A, Cades Jessica, Mazzacurati Lucia, Neumann Neil M, Khetarpal Susheel K, Chatterjee Suman, Wang Hailun, Attar Myriam A, Huang Eric H-B, Chatley Sarah N, Nugent Katriana, Somasundaram Ashwin, Engh Johnathan A, Ewald Andrew J, Cho Yoon-Jae, Rudin Charles M, Tran Phuoc T, Burns Timothy F

Abstract excerpt

TWIST1, an epithelial-mesenchymal transition (EMT) transcription factor, is critical for oncogene-driven non-small cell lung cancer (NSCLC) tumorigenesis. Given the potential of TWIST1 as a therapeutic target, a chemical-bioinformatic approach using connectivity mapping (CMAP) analysis was used to identify TWIST1 inhibitors. Characterization of the top ranked candidates from the unbiased screen revealed that...

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Source

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Identifiers

PMID: 28851812
DOI: 10.1158/1541-7786.MCR-17-0298
PMCID: PMC5712248

Genes

TWIST1
KRAS
EGFR
MET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer.PMID 28851812Read ↗

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