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Article

The Amyloid Phenomenon and Its Links with Human Disease.

Cold Spring Harbor perspectives in biology - 1 Jun 2017

Dobson Christopher M

Abstract excerpt

The ability of normally soluble proteins to convert into amyloid fibrils is now recognized to be a generic phenomenon. The overall cross-β architecture of the core elements of such structures is closely similar for different amino acid sequences, as this architecture is dominated by interactions associated with the common polypeptide main chain. In contrast, the multiplicity of complex and intricate structures of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28062560
DOI: 10.1101/cshperspect.a023648
PMCID: PMC5453392

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